AHU HIRE SECRETS

Close to 80% of TTP is triggered by deficient action of ADAMTS13. ADAMTS13 deficiency is often constitutive, because of biallelic ADAMTS13 pathogenic variants; or obtained, on account of an inhibitory antibody. Evaluation of ADAMTS13 activity is done using exams dependant on the capability on the protease to cleave typical VWF multimers in vitro (e